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8580 matches
showing page 1 of 429
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organism
protein
1)
Escherichia coli K12
rmf -
Ribosome
modulation
factor
; During stationary phase, converts 70S
ribosomes
to an immature dimeric form (90S
ribosomes
) which are converted to inactive 100S
ribosomes
(a process called
ribosomal
hibernation) by the hibernation promoting
factor
HPF. Inactivates
ribosomes
by covering the peptidyl transferase (PTase) center of the 23S rRNA and the entrance of peptide exit tunnel. However crystallization with T.thermophilus 70S
ribosomes
shows it binds near the 3'-end of the 16S rRNA near the anti-Shine-Dalgarno sequence, where it would sterically hinder translation inititation. In this cr [...]
[a.k.a. b0953, AAC74039.1, ABE-0003227,
Ribosome modulation factor
,
ribosome modulation factor
, ...]
2)
Homo sapiens
RCC1L - RCC1-like G exchanging
factor
-like protein; Guanine nucleotide exchange
factor
(GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion. Plays an essential role in mitochondrial
ribosome
biogenesis. As a component of a functional protein-RNA
module
, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial
ribosomal
RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphoryl [...]
[a.k.a. Q96I51, WBSCR16, NP_001268370.1]
3)
Homo sapiens
RPS6KA3 -
Ribosomal
protein S6 kinase alpha-3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription
factors
CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by
modulating
mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subseq [...]
[a.k.a. R-HSA-388396, BC096301, XP_011543858]
4)
Homo sapiens
RPS6KA1 -
Ribosomal
protein S6 kinase alpha-1; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription
factors
CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by
modulating
mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activa [...]
[a.k.a. R-HSA-388396, hsa:6195, ENST00000531113.5]
5)
Mus musculus
Rcc1l - RCC1-like G exchanging
factor
-like protein; Guanine nucleotide exchange
factor
(GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion. Plays an essential role in mitochondrial
ribosome
biogenesis. As a component of a functional protein-RNA
module
, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial
ribosomal
RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphoryl [...]
[a.k.a. XR_377117, XM_006504539, XM_011240917.2]
6)
Mus musculus
Rps6ka3 -
Ribosomal
protein S6 kinase alpha-3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription
factors
CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by
modulating
mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subseq [...]
[a.k.a. UPI0000EE0658, XP_006528751, ENSMUST00000149939.1]
7)
Mus musculus
Rps6ka1 -
Ribosomal
protein S6 kinase alpha-1; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription
factors
CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by
modulating
mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activa [...]
[a.k.a. R-MMU-442755, R-MMU-166058, R-MMU-975871]
8)
Escherichia coli K12
hpf -
Ribosome
hibernation promoting
factor
HPF; During stationary phase, promotes and stabilizes dimerization of 70S
ribosomes
by the
ribosome
modulation
factor
(RMF), leading to the formation of inactive 100S
ribosomes
. Converts immature 90S particles formed by RMF into 100S
ribosomes
. Crystallization with T.thermophilus 70S
ribosomes
shows it binds in the channel between the head and body of the 30S subunit, where mRNA, tRNAs, initiation
factors
IF1 and IF3 and elongation
factor
G would bind; however RMF is still able to bind. In this crystal binding of HPF induces movement of the 30S hea [...]
[a.k.a. AAC76235.1, b3203, AAC76235]
9)
Escherichia coli K12
ettA - Energy-dependent translational throttle A; A translation
factor
that gates the progression of the 70S
ribosomal
initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S
ribosome
E-site where it
modulates
the state of the translating
ribosome
during subunit translocation. Stimulates dipeptide bond synthesis in the presence of ATP (cell in high energy state), but inhibits dipeptide synthesis in the presence of ADP (cell in low energy state), and thus may control translation in [...]
[a.k.a. b4391, AAC77344.1, Q2M5S6]
10)
Saccharomyces cerevisiae
SFP1 - Transcription
factor
SFP1; Regulates transcription of
ribosomal
protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and
modulates
cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion.
[a.k.a. YLR403W, NM_001182291.1, NP_013507]
11)
Escherichia coli K12
nusB - Transcription antitermination protein; Involved in transcription antitermination. Required for transcription of
ribosomal
RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the
ribosomal
RNA (rrn) operons. The affinity of NusB for the boxA RNA sequence is significantly increased in the presence of the
ribosomal
protein S10. NusB may serve as a loading
factor
that ensures efficient entry of S10 into the transcription complexes. It also
modulates
the rrn boxA-mediated transcription elongation rates.
[a.k.a. b0416, AAC73519.1, transcription antitermination protein]
12)
Escherichia coli K12
infA - Translation initiation
factor
IF-1; One of the essential components for the initiation of protein synthesis. Binds in the vicinity of the A-site. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl- tRNA(fMet) subsequently binds. Helps
modulate
mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S
ribosomal
subunit, IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
[a.k.a. b0884, AAC73970.1, NP_415404]
13)
Escherichia coli K12
nusG - Transcription termination
factor
; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho,
modulates
most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in
ribosomal
RNA and phage lambda N-mediated transcription [...]
[a.k.a. b3982, AAC76956.1, Transcription termination factor NusG]
14)
Aeromonas aquatica
APJ17491.1 -
Ribosome
modulation
factor
; Derived by automated computational analysis using gene prediction method: Protein Homology.
[a.k.a. BOQ57_10860,
Ribosome modulation factor
,
ribosome modulation factor
]
15)
Aeromonas hydrophila
rmf - Conserved domain protein; During stationary phase, converts 70S
ribosomes
to an inactive dimeric form (100S
ribosomes
); Belongs to the
ribosome
modulation
factor
family.
[a.k.a. AHA_2281, ABK38478.1, aaj:BOQ57_10860,
Ribosome modulation factor
]
16)
Aeromonas media
rmf -
Ribosome
modulation
factor
; During stationary phase, converts 70S
ribosomes
to an inactive dimeric form (100S
ribosomes
); Belongs to the
ribosome
modulation
factor
family.
[a.k.a. B224_2316, AHX60944.1, A0A023RK36_AERME,
Ribosome modulation factor
,
ribosome modulation factor
, ...]
17)
Aeromonas salmonicida masoucida
rmf -
Ribosome
modulation
factor
.
[a.k.a. ASA01S_117_00050, GAJ50791.1, GAJ50791,
Ribosome modulation factor
,
ribosome modulation factor
, ...]
18)
Aidingimonas halophila
rmf -
Ribosome
modulation
factor
; During stationary phase, converts 70S
ribosomes
to an inactive dimeric form (100S
ribosomes
); Belongs to the
ribosome
modulation
factor
family.
[a.k.a. SDX80138.1, SAMN05443545_107187, A0A1H3EPU2,
Ribosome modulation factor
,
ribosome modulation factor
, ...]
19)
Alcanivorax borkumensis
rmf -
Ribosome
modulation
factor
; During stationary phase, converts 70S
ribosomes
to an inactive dimeric form (100S
ribosomes
); Belongs to the
ribosome
modulation
factor
family.
[a.k.a. ABO_1004, CAL16452.1, CAL16452,
Ribosome modulation factor
,
ribosome modulation factor
, ...]
20)
Alcanivorax dieselolei
rmf -
Ribosome
modulation
factor
; During stationary phase, converts 70S
ribosomes
to an inactive dimeric form (100S
ribosomes
); Belongs to the
ribosome
modulation
factor
family.
[a.k.a. AFT70087.1, B5T_01812, K0CEJ2_ALCDB,
Ribosome modulation factor
]
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